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However, the mature microRNA found from one arm of the hairpin is usually much more abundant than that found from the other arm, [2] in which case, an asterisk following the name indicates the mature species found at low levels from the opposite arm of a hairpin.

Plant miRNAs usually have near-perfect pairing with their mRNA targets, which induces gene repression through cleavage of the target transcripts.

Estimates of the average number of unique messenger RNAs that are targets for repression by a typical miRNA vary, depending on the estimation method, [39] but multiple approaches show that mammalian miRNAs can have many unique targets.

For example, an analysis of the miRNAs highly conserved in vertebrates shows that each has, on average, roughly conserved targets.

Other B cell malignancies followed. This increases the diversity and scope of miRNA action beyond that implicated from the genome alone.

These hairpin loop structures are composed of about 70 nucleotides each. Each hairpin is flanked by sequences necessary for efficient processing.

Sequence motifs downstream of the pre-miRNA that are important for efficient processing have been identified. Pre-miRNAs that are spliced directly out of introns, bypassing the Microprocessor complex, are known as " Mirtrons.

RNA editing can halt nuclear processing for example, of pri-miR, leading to degradation by the ribonuclease Tudor-SN and alter downstream processes including cytoplasmic miRNA processing and target specificity e.

Pre-miRNA hairpins are exported from the nucleus in a process involving the nucleocytoplasmic shuttler Exportin Exportinmediated transport to the cytoplasm is energy-dependent, using GTP bound to the Ran protein.

The imperfect nature of the miRNA: For example, human pre-miRNA 92b adopts a G-quadruplex structure which is resistant to the Dicer mediated cleavage in the cytoplasm.

While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media.

Instead of being cleaved by two different enzymes, once inside and once outside the nucleus, both cleavages of the plant miRNA are performed by a Dicer homolog, called Dicer-like1 DL1.

DL1 is expressed only in the nucleus of plant cells, which indicates that both reactions take place inside the nucleus. Dicer processing of the pre-miRNA is thought to be coupled with unwinding of the duplex.

In some cases, both strands of the duplex are viable and become functional miRNA that target different mRNA populations.

Some argonautes, for example human Ago2, cleave target transcripts directly; argonautes may also recruit additional proteins to achieve translational repression.

In the absence of complementarity, silencing is achieved by preventing translation. Some miRNAs work as buffers of random gene expression changes arising due to stochastic events in transcription, translation and protein stability.

Such regulation is typically achieved by the virtue of negative feedback loops or incoherent feed-forward loop uncoupling protein output from mRNA transcription.

In what has been called a "Use it or lose it" strategy, Argonaute may preferentially retain miRNAs with many targets over miRNAs with few or no targets, leading to degradation of the non-targeting molecules.

Similar enzymes are encoded in animal genomes, but their roles have not been described. However, uridylation may also protect some miRNAs; the consequences of this modification are incompletely understood.

Uridylation of some animal miRNAs has been reported. An extra A added to the end of mammalian miR , a liver-enriched miRNA important in hepatitis C , stabilizes the molecule and plant miRNAs ending with an adenine residue have slower decay rates.

The function of miRNAs appears to be in gene regulation. Recent work on miR in zebrafish, as well as on bantam-miRNA and miR-9 in Drosophila cultured cells, shows that translational repression is caused by the disruption of translation initiation , independent of mRNA deadenylation.

Nine mechanisms of miRNA action are described and assembled in a unified mathematical model: It is often impossible to discern these mechanisms using experimental data about stationary reaction rates.

Nevertheless, they are differentiated in dynamics and have different kinetic signatures. Interactions between microRNAs and complementary sequences on genes and even pseudogenes that share sequence homology are thought to be a back channel of communication regulating expression levels between paralogous genes.

New microRNAs are created in multiple ways. However, the difference in how these microRNAs function and the way they are processed suggests that microRNAs arose independently in plants and animals.

Focusing on the animals, the genome of Mnemiopsis leidyi [] appears to lack recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha , which are critical to canonical microRNA biogenesis.

It is the only animal thus far reported to be missing Drosha. MicroRNAs play a vital role in the regulation of gene expression in all non-ctenophore animals investigated thus far except for Trichoplax adhaerens , the only known member of the phylum Placozoa.

Across all species, in excess of different miRNAs had been identified by March While researchers focused on miRNA expression in physiological and pathological processes, various technical variables related to microRNA isolation emerged.

The stability of stored miRNA samples has been questioned. This makes it necessary to cool samples on ice and use RNase -free equipment. Variations of this method achieve absolute or relative quantification.

The locked conformation of LNA results in enhanced hybridization properties and increases sensitivity and selectivity, making it ideal for detection of short miRNA.

High-throughput quantification of miRNAs is error prone, for the larger variance compared to mRNAs that comes with methodological problems.

Just as miRNA is involved in the normal functioning of eukaryotic cells, so has dysregulation of miRNA been associated with disease.

A manually curated, publicly available database, miR2Disease , documents known relationships between miRNA dysregulation and human disease.

A mutation in the seed region of miR, causes hereditary progressive hearing loss. A mutation in the seed region of miR, causes hereditary keratoconus with anterior polar cataract.

The first human disease known to be associated with miRNA deregulation was chronic lymphocytic leukemia. Many other miRNAs also have links with cancer and accordingly are sometimes referred to as " oncomirs ".

Another role for miRNA in cancers is to use their expression level for prognosis. Furthermore, specific miRNAs may be associated with certain histological subtypes of colorectal cancer.

For instance, expression levels of miR and miR have been shown to be increased in mucinous colorectal cancers and mucin-producing Ulcerative Colitis-associated colon cancers, but not in sporadic colonic adenocarcinoma that lack mucinous components.

Hepatocellular carcinoma cell proliferation may arise from miR interaction with MAP2K3, a tumor repressor gene. Those with a rapid response to initial treatment may benefit from truncated treatment regimens, showing the value of accurate disease response measures.

Cell-free miRNA are highly stable in blood, are overexpressed in cancer and are quantifiable within the diagnostic laboratory. In classical Hodgkin lymphoma , plasma miR, miR, and miR are promising disease response biomarkers.

They can be performed at each consultation to assess disease response and detect relapse. MicroRNAs have the potential to be used as tools or targets for treatment of different cancers.

A significant number of cervical cancer samples were found to have downregulated expression of miR Additionally, miR works to promote apoptosis of cervical cancer cells, through its direct target hedgehog pathway transcription factor, Gli3.

DNA damage is considered to be the primary underlying cause of cancer. Such damage can cause mutational errors during DNA replication due to error-prone translesion synthesis.

Accumulated damage can also cause epigenetic alterations due to errors during DNA repair. HMGA expression is almost undetectable in differentiated adult tissues, but is elevated in many cancers.

Human neoplasias, including thyroid, prostatic, cervical, colorectal, pancreatic and ovarian carcinomas, show a strong increase of HMGA1a and HMGA1b proteins.

The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart.

This revealed that miRNAs play an essential role during its development. Murine microRNA is a potential biomarker i. These findings were observed in ligated carotid arteries of mice to mimic the effects of d-flow.

Within 24 hours, pre-existing immature miR formed mature miR suggesting that miR is flow-sensitive. Arterial ECM is mainly composed of collagen and elastin fibers, providing the structural support and recoil properties of arteries.

Consistent with these findings, inhibition of pre-miR increases expression of TIMP3 in cells, even when exposed to turbulent flow.

These modules would have used a Soyuz propulsion module, as in Soyuz and Progress , and the descent and orbital modules would have been replaced with a long laboratory module.

The docking ports were reinforced to accommodate tonne short-ton space station modules based on the TKS spacecraft. KB Salyut began work in , and drawings were released in and New systems incorporated into the station included the Salyut 5B digital flight control computer and gyrodyne flywheels taken from Almaz , Kurs automatic rendezvous system , Luch satellite communications system, Elektron oxygen generators, and Vozdukh carbon dioxide scrubbers.

By early , work on Mir had halted while all resources were being put into the Buran programme in order to prepare the Buran spacecraft for flight testing.

It was clear that the planned processing flow could not be followed and still meet the launch date. The module arrived at the launch site on 6 May, with of cables requiring rework based on the results of tests to the ground test model at Khrunichev.

In October, the base block was rolled outside its cleanroom to carry out communications tests. The first launch attempt on 16 February was scrubbed when the spacecraft communications failed, but the second launch attempt, on 19 February at The orbital assembly of Mir began on 19 February with the launch of the Proton-K rocket.

Four of the six modules which were later added Kvant -2 in , Kristall in , Spektr in and Priroda in followed the same sequence to be added to the main Mir complex.

Firstly, the module would be launched independently on its own Proton-K and chase the station automatically. The arm would then lift the module away from the forward docking port and rotate it on to the radial port where it was to mate, before lowering it to dock.

The node was equipped with only two Konus drogues, which were required for dockings. This meant that, prior to the arrival of each new module, the node would have to be depressurised to allow spacewalking cosmonauts to manually relocate the drogue to the next port to be occupied.

The other two expansion modules, Kvant -1 in and the docking module in , followed different procedures. Kvant -1, having, unlike the four modules mentioned above, no engines of its own, was launched attached to a tug based on the TKS spacecraft which delivered the module to the aft end of the core module instead of the docking node.

Once hard docking had been achieved, the tug undocked and deorbited itself. Atlantis then docked, via the module, to Kristall , then left the module behind when it undocked later in the mission.

First generation stations such as Salyut 1 and Skylab had monolithic designs, consisting of one module with no resupply capability; the second generation stations Salyut 6 and Salyut 7 comprised a monolithic station with two ports to allow consumables to be replenished by cargo spacecraft such as Progress.

In its completed configuration, the space station consisted of seven different modules, each launched into orbit separately over a period of ten years by either Proton-K rockets or Space Shuttle Atlantis.

In addition to the pressurised modules, Mir featured several external components. The largest component was the Sofora girder, a large scaffolding-like structure consisting of 20 segments which, when assembled, projected 14 metres from its mount on Kvant A self-contained thruster block, the VDU, was mounted on the end of Sofora and was used to augment the roll-control thrusters on the core module.

This girder, a small prototype of a structure intended to be used on Mir -2 to hold large parabolic dishes away from the main station structure, was 5 metres long and used as a mounting point for externally mounted exposure experiments.

To assist in moving objects around the exterior of the station during EVAs , Mir featured two Strela cargo cranes mounted to the sides of the core module, used for moving spacewalking cosmonauts and parts.

The cranes consisted of telescopic poles assembled in sections which measured around 1. Each module was fitted with external components specific to the experiments that were carried out within that module, the most obvious being the Travers antenna mounted to Priroda.

This synthetic aperture radar consisted of a large dish-like framework mounted outside the module, with associated equipment within, used for Earth observations experiments, as was most of the other equipment on Priroda , including various radiometers and scan platforms.

This backpack was designed to assist cosmonauts in moving around the station and the planned Buran in a manner similar to the US Manned Maneuvering Unit , but it was only used once, during EO Photovoltaic PV arrays powered Mir.

The station itself also had to be oriented to ensure optimum illumination of the arrays. The solar arrays themselves were launched and installed over a period of eleven years, more slowly than originally planned, with the station continually suffering from a shortage of power as a result.

This relocation was begun in , when the panels were retracted and the left panel installed on Kvant By this time all the arrays had degraded and were supplying much less power.

The first of these, the Mir cooperative solar array, consisted of American photovoltaic cells mounted on a Russian frame. This boost was generally performed by Progress resupply vessels, although during the Shuttle- Mir programme the task was performed by US Space Shuttles, and, prior to the arrival of Kvant-1 , the engines on the core module could also accomplish the task.

Radio links were also used during rendezvous and docking procedures and for audio and video communication between crew members, flight controllers and family members.

As a result, Mir was equipped with several communication systems used for different purposes. The station communicated directly with the ground via the Lira antenna mounted to the core module.

The Lira antenna also had the capability to use the Luch data relay satellite system which fell into disrepair in the s and the network of Soviet tracking ships deployed in various locations around the world which also became unavailable in the s.

While the constant free fall of the station offered a perceived sensation of weightlessness , the onboard environment was not one of weightlessness or zero gravity.

The environment was often described as microgravity. This state of perceived weightlessness was not perfect, being disturbed by five separate effects: The Elektron system generated oxygen.

Bottled oxygen and solid fuel oxygen generation SFOG canisters, a system known as Vika , provided backup. Carbon dioxide was removed from the air by the Vozdukh system.

Similar systems are presently used on the ISS. Intercosmos "ИнтерКосмос" Interkosmos was a Soviet Union space exploration programme which allowed members from the military forces of allied Warsaw Pact countries to participate in manned and unmanned space exploration missions.

Participation was also made available to governments of countries, such as France and India. Various European astronauts visited Mir as part of several cooperative programmes: In the early s, NASA planned to launch a modular space station called Freedom as a counterpart to Mir , while the Soviets were planning to construct Mir -2 in the s as a replacement for the station.

The post-Soviet economic chaos in Russia also led to the cancellation of Mir -2, though only after its base block, DOS-8 , had been constructed.

Bush and Russian president Boris Yeltsin agreed to cooperate on space exploration. The project prepared the way for further cooperative space ventures, specifically, "Phase Two" of the joint project, the construction of the ISS.

The programme was announced in ; the first mission started in , and the project continued until its scheduled completion in Eleven Space Shuttle missions, a joint Soyuz flight, and almost cumulative days in space for US astronauts occurred over the course of seven long-duration expeditions.

It commonly housed three crew members, but was capable of supporting as many as six for up to a month. The station was designed to remain in orbit for around five years; it remained in orbit for fifteen.

The windows were covered during night hours to give the impression of darkness because the station experienced 16 sunrises and sunsets a day.

A typical day for the crew began with a wake-up at Work was conducted from Three more hours of work and another hour of exercise followed lunch, and the crews began preparing for their evening meal at about The cosmonauts were free to do as they wished in the evening, and largely worked to their own pace during the day.

NASA astronaut Jerry Linenger related how life on board Mir was structured and lived according to the detailed itineraries provided by ground control.

Every second on board was accounted for and all activities were timetabled. After working some time on Mir , Linenger came to feel that the order in which his activities were allocated did not represent the most logical or efficient order possible for these activities.

He decided to perform his tasks in an order that he felt enabled him to work more efficiently, be less fatigued, and suffer less from stress.

Linenger noted that his comrades on Mir did not "improvise" in this way, and as a medical doctor he observed the effects of stress on his comrades that he believed was the outcome of following an itinerary without making modifications to it.

Despite this, he commented that his comrades performed all their tasks in a supremely professional manner. Astronaut Shannon Lucid , who set the record for longest stay in space by a woman while aboard Mir surpassed by Sunita Williams 11 years later on the ISS , also commented about working aboard Mir saying "I think going to work on a daily basis on Mir is very similar to going to work on a daily basis on an outstation in Antarctica.

The big difference with going to work here is the isolation, because you really are isolated. You really are on your own.

The most significant adverse effects of long-term weightlessness are muscle atrophy and deterioration of the skeleton , or spaceflight osteopenia.

Other significant effects include fluid redistribution, a slowing of the cardiovascular system , decreased production of red blood cells , balance disorders, and a weakening of the immune system.

Lesser symptoms include loss of body mass, nasal congestion, sleep disturbance, excess flatulence , and puffiness of the face.

These effects begin to reverse quickly upon return to the Earth. To prevent some of these effects, the station was equipped with two treadmills in the core module and Kvant -2 and a stationary bicycle in the core module ; each cosmonaut was to cycle the equivalent of 10 kilometres 6.

Researchers believe that exercise is a good countermeasure for the bone and muscle density loss that occurs in low-gravity situations. The user is first fastened to the toilet seat, which was equipped with spring-loaded restraining bars to ensure a good seal.

A lever operated a powerful fan and a suction hole slid open: Solid waste was collected in individual bags which were stored in an aluminium container.

Full containers were transferred to Progress spacecraft for disposal. Liquid waste was evacuated by a hose connected to the front of the toilet, with anatomically appropriate "urine funnel adapters" attached to the tube so both men and women could use the same toilet.

Waste was collected and transferred to the Water Recovery System, where it was recycled back into drinking water, although this was usually used to produce oxygen via the Elektron system.

Mir featured a shower, the Bania , located in Kvant It was an improvement on the units installed in previous Salyut stations, but proved difficult to use due to the time required to set up, use, and stow.

The shower, which featured a plastic curtain and fan to collect water via an airflow, was later converted into a steam room; it eventually had its plumbing removed and the space was reused.

When the shower was unavailable, crew members washed using wet wipes, with soap dispensed from a toothpaste tube-like container, or using a washbasin equipped with a plastic hood, located in the core module.

Crews were also provided with rinse-less shampoo and edible toothpaste to save water. On a visit to Mir , bacteria and larger organisms were found to have proliferated in water globules formed from moisture that had condensed behind service panels.

The station provided two permanent crew quarters, the Kayutkas , phonebox-sized booths set towards the rear of the core module, each featuring a tethered sleeping bag, a fold-out desk, a porthole, and storage for personal effects.

Visiting crews had no allocated sleep module, instead attaching a sleeping bag to an available space on a wall; US astronauts installed themselves within Spektr until a collision with a Progress spacecraft caused the depressurisation of that module.

Most of the food eaten by station crews was frozen, refrigerated or canned. Menus were prepared by the cosmonauts, with the help of a dietitian , before their flight to the station.

Meals were spaced out through the day to aid assimilation. Usually, crews drank tea, coffee and fruit juices, but, unlike the ISS, the station also had a supply of cognac and vodka for special occasions.

In the s samples of extremophile moulds were taken from Mir. By the time of its decommission in , the number of known different micro-organisms had grown to As space stations get older, the problems with contamination get worse.

Some biologists were concerned about the mutant fungi being a major microbiological hazard for humans, and reaching Earth in the splashdown, after having been in an isolated environment for 15 years.

Mir was visited by a total of 28 long-duration or "principal" crews, each of which was given a sequential expedition number formatted as EO-X.

Expeditions varied in length from the day flight of the crew of EO to the day flight of Valeri Polyakov , but generally lasted around six months.

Due to the pressure to launch the station on schedule, mission planners were left without Soyuz spacecraft or modules to launch to the station at first.

It was decided to launch Soyuz T on a dual mission to both Mir and Salyut 7. During their nearly day stay on Mir , they brought the station online and checked its systems.

They unloaded two Progress spacecraft launched after their arrival, Progress 25 and Progress On 5 May , they undocked from Mir for a day-long journey to Salyut 7.

Soyuz T redocked with Mir on 26 June and delivered the experiments and 20 instruments, including a multichannel spectrometer.

The EO-1 crew spent their last 20 days on Mir conducting Earth observations before returning to Earth on 16 July , leaving the new station unoccupied.

During their stay, the Kvant -1 module, launched on 30 March , arrived. Kvant -1 was originally planned to dock with Salyut 7 ; due to technical problems during its development, it was reassigned to Mir.

The module carried the first set of six gyroscopes for attitude control. The module also carried instruments for X-ray and ultraviolet astrophysical observations.

The initial rendezvous of the Kvant -1 module with Mir on 5 April was troubled by the failure of the onboard control system.

After the failure of the second attempt to dock, the resident cosmonauts, Yuri Romanenko and Aleksandr Laveykin , conducted an EVA to fix the problem.

They found a trash bag which had been left in orbit after the departure of one of the previous cargo ships and was now located between the module and the station, which prevented the docking.

After removing the bag, docking was completed on 12 April. The Soyuz TM-2 launch was the beginning of a string of 6 Soyuz launches and three long-duration crews between 5 February and 27 April The launch of Soyuz TM-8 on 5 September marked the beginning of the longest human presence in space, until 23 October , when this record was surpassed by the ISS.

The Kvant-2 and Kristall modules were now ready for launch. Alexander Viktorenko and Aleksandr Serebrov docked with Mir and brought the station out of its five-month hibernation.

After a day delay caused by faulty computer chips, Kvant -2 was launched on 26 November Kvant -2 added a second set of gyrodines to Mir , and brought the new life support systems for recycling water and generating oxygen, reducing dependence on ground resupply.

The module featured a large airlock with a one-metre hatch. While docking, the EO-5 crew noted that three thermal blankets on the ferry were loose, potentially creating problems on reentry, but it was decided that they would be manageable.

Their stay on board Mir saw the addition of the Kristall module, launched 31 May The first docking attempt on 6 June was aborted due to an attitude control thruster failure.

Kristall arrived at the front port on 10 June and was relocated to the lateral port opposite Kvant -2 the next day, restoring the equilibrium of the complex.

Kristall contained furnaces for use in producing crystals under microgravity conditions hence the choice of name for the module. The module was also equipped with biotechnology research equipment, including a small greenhouse for plant cultivation experiments which was equipped with a source of light and a feeding system, in addition to equipment for astronomical observations.

Although they were never used in a Buran docking, they were useful later during the Shuttle- Mir programme, providing a berthing location for US Space Shuttles.

The crew launched as Soviet citizens and returned to earth as Russians. Bush announced what would later become the Shuttle- Mir programme, a cooperative venture which proved useful to the cash-strapped Roskosmos and led to the eventual completion and launch of Spektr and Priroda.

Throughout the period following the collapse of the USSR, crews on Mir experienced occasional reminders of the economic chaos occurring in Russia.

The initial cancellation of Spektr and Priroda was the first such sign, followed by the reduction in communications as a result of the fleet of tracking ships being withdrawn from service by Ukraine.

Various Progress spacecraft had parts of their cargoes missing, either because the consumable in question had been unavailable, or because the ground crews at Baikonur had looted them.

The problems became particularly obvious during the launch of the EO crew aboard Soyuz TM in July; shortly before launch there was a black-out at the pad, and the power supply to the nearby city of Leninsk failed an hour after launch.

The EO crew departed on 22 July, and soon after Mir passed through the annual Perseid meteor shower , during which the station was hit by several particles.

The undocking was unusual in that the spacecraft was to pass along Kristall in order to obtain photographs of the APAS to assist in the training of space shuttle pilots.

Due to an error in setting up the control system, the spacecraft struck the station a glancing blow during the manoeuvre, scratching the exterior of Kristall.

The launch of Soyuz TM , carrying the EO crew, was delayed due to the unavailability of a payload fairing for the booster that was to carry it, but the spacecraft eventually left Earth on 1 July and docked two days later.

They stayed only four months to allow the Soyuz schedule to line up with the planned space shuttle manifest, and so Polyakov greeted a second resident crew in October, prior to the undocking of Soyuz TM, when the EO crew arrived in Soyuz TM The EO crew left a few days later, with Polyakov completing his record-breaking day spaceflight.

During EO, the Spektr science module which served as living and working space for American astronauts was launched aboard a Proton rocket and docked to the station, carrying research equipment from America and other nations.

This mission saw the first joint US spacewalk on Mir take place deploying the Mir Environmental Effects Payload package on the docking module.

This, the fourth docking, saw John Blaha transferring onto Mir to take his place as resident US astronaut. The power failure also caused a loss of attitude control , which led to an uncontrolled "tumble" through space.

Following the 8 June departure of Discovery , the EO crew of Budarin and Musabayev remained on Mir , completing materials experiments and compiling a station inventory.

On 2 July, Roskosmos director Yuri Koptev announced that, due to a lack of funding to keep Mir active, the station would be deorbited in June Roscosmos confirmed that it would not fund Mir past the set deorbit date.

The crew carried out three EVAs to retrieve experiments and deploy a prototype communications antenna on Sofora. On 1 June it was announced that the deorbit of the station would be delayed by six months to allow time to seek alternative funding to keep the station operating.

The rest of the expedition was spent preparing the station for its deorbit; a special analog computer was installed and each of the modules, starting with the docking module, was mothballed in turn and sealed off.

The crew loaded their results into Soyuz TM and departed Mir on 28 August , ending a run of continuous occupation, which had lasted for eight days short of ten years.

The privately funded Soyuz TM mission by MirCorp , launched on 4 April , carried two crew members, Sergei Zalyotin and Aleksandr Kaleri , to the station for two months to do repair work with the hope of proving that the station could be made safe.

This began with the docking of Progress M , a modified version of the Progress-M carrying 2. Major destruction of the station began around Mir was primarily supported by the Russian Soyuz and Progress spacecraft and had two ports available for docking them.

Soyuz spacecraft provided manned access to and from the station allowing for crew rotations and cargo return, and also functioned as a lifeboat for the station, allowing for a relatively quick return to Earth in the event of an emergency.

A total of 31 30 manned, 1 unmanned Soyuz spacecraft flew to the station over a fourteen-year period. The unmanned Progress cargo vehicles were only used to resupply the station, carrying a variety of cargoes including water, fuel, food and experimental equipment.

The spacecraft were not equipped with reentry shielding and so, unlike their Soyuz counterparts, were incapable of surviving reentry.

In addition to the routine Soyuz and Progress flights, it was anticipated that Mir would also be the destination for flights by the Soviet Buran space shuttle , which was intended to deliver extra modules based on the same "37K" bus as Kvant -1 and provide a much improved cargo return service to the station.

One port was to be used for Buran ; the other for the planned Pulsar X-2 telescope, also to be delivered by Buran.

Stehen mir caps test - indefinitely

Ein ertappter Einbrecher attackierte zwei Bewohnerinnen mit einer Schere. Zwei Further Familien aus dem Ortsteil Dieberg erzählen. Der Lebensmittelladen in Brennberg wird seit von Hans Haimerl betrieben. Interessante Aussagen von Fachmagazinen finden sich lediglich zu sportlichen Caps. Diese Art kauft ein Cap-Träger somit perfekt an den Kopf angepasst. Kann mir wer helfen?: Das ist vor allem bei Flexfit-Caps der Fall.

mir test stehen caps - with

Ich fühle mich nicht wohl unter Menschen, ich mag sie alle nicht! Wieso sind Caps von den Oakland Raiders in Deutschland so beliebt? Diese können hinten mit einem Verschluss verstellt werden. Was sagen Käufer zu Caps? Insbesondere dann nicht, wenn anstelle des Christkinds plötzlich Grippe und Co. Sollte sie aber dreckig werden, muss man bei der Pflege vorsichtig sein. Caps gibt es auch für Mädchen. Das ist vor allem bei Flexfit-Caps der Fall. Aber wie können sich alle Menschen denn immernoch so vom aussehen unterscheiden? Habt ihr vlt einen Shop basketball australien Internet wo man günstig Caps kaufen kann? Zwei Further Familien aus dem Ortsteil Dieberg erzählen. Wem die Form nicht so wichtig ist, kann einen Schonwaschgang bei 30 Grad wagen. LA, New York oder Miami. Sie haben ein flaches Schild, sind nicht so hoch und liegen enger am Kopf an.

The docking ports were reinforced to accommodate tonne short-ton space station modules based on the TKS spacecraft. KB Salyut began work in , and drawings were released in and New systems incorporated into the station included the Salyut 5B digital flight control computer and gyrodyne flywheels taken from Almaz , Kurs automatic rendezvous system , Luch satellite communications system, Elektron oxygen generators, and Vozdukh carbon dioxide scrubbers.

By early , work on Mir had halted while all resources were being put into the Buran programme in order to prepare the Buran spacecraft for flight testing.

It was clear that the planned processing flow could not be followed and still meet the launch date. The module arrived at the launch site on 6 May, with of cables requiring rework based on the results of tests to the ground test model at Khrunichev.

In October, the base block was rolled outside its cleanroom to carry out communications tests. The first launch attempt on 16 February was scrubbed when the spacecraft communications failed, but the second launch attempt, on 19 February at The orbital assembly of Mir began on 19 February with the launch of the Proton-K rocket.

Four of the six modules which were later added Kvant -2 in , Kristall in , Spektr in and Priroda in followed the same sequence to be added to the main Mir complex.

Firstly, the module would be launched independently on its own Proton-K and chase the station automatically.

The arm would then lift the module away from the forward docking port and rotate it on to the radial port where it was to mate, before lowering it to dock.

The node was equipped with only two Konus drogues, which were required for dockings. This meant that, prior to the arrival of each new module, the node would have to be depressurised to allow spacewalking cosmonauts to manually relocate the drogue to the next port to be occupied.

The other two expansion modules, Kvant -1 in and the docking module in , followed different procedures. Kvant -1, having, unlike the four modules mentioned above, no engines of its own, was launched attached to a tug based on the TKS spacecraft which delivered the module to the aft end of the core module instead of the docking node.

Once hard docking had been achieved, the tug undocked and deorbited itself. Atlantis then docked, via the module, to Kristall , then left the module behind when it undocked later in the mission.

First generation stations such as Salyut 1 and Skylab had monolithic designs, consisting of one module with no resupply capability; the second generation stations Salyut 6 and Salyut 7 comprised a monolithic station with two ports to allow consumables to be replenished by cargo spacecraft such as Progress.

In its completed configuration, the space station consisted of seven different modules, each launched into orbit separately over a period of ten years by either Proton-K rockets or Space Shuttle Atlantis.

In addition to the pressurised modules, Mir featured several external components. The largest component was the Sofora girder, a large scaffolding-like structure consisting of 20 segments which, when assembled, projected 14 metres from its mount on Kvant A self-contained thruster block, the VDU, was mounted on the end of Sofora and was used to augment the roll-control thrusters on the core module.

This girder, a small prototype of a structure intended to be used on Mir -2 to hold large parabolic dishes away from the main station structure, was 5 metres long and used as a mounting point for externally mounted exposure experiments.

To assist in moving objects around the exterior of the station during EVAs , Mir featured two Strela cargo cranes mounted to the sides of the core module, used for moving spacewalking cosmonauts and parts.

The cranes consisted of telescopic poles assembled in sections which measured around 1. Each module was fitted with external components specific to the experiments that were carried out within that module, the most obvious being the Travers antenna mounted to Priroda.

This synthetic aperture radar consisted of a large dish-like framework mounted outside the module, with associated equipment within, used for Earth observations experiments, as was most of the other equipment on Priroda , including various radiometers and scan platforms.

This backpack was designed to assist cosmonauts in moving around the station and the planned Buran in a manner similar to the US Manned Maneuvering Unit , but it was only used once, during EO Photovoltaic PV arrays powered Mir.

The station itself also had to be oriented to ensure optimum illumination of the arrays. The solar arrays themselves were launched and installed over a period of eleven years, more slowly than originally planned, with the station continually suffering from a shortage of power as a result.

This relocation was begun in , when the panels were retracted and the left panel installed on Kvant By this time all the arrays had degraded and were supplying much less power.

The first of these, the Mir cooperative solar array, consisted of American photovoltaic cells mounted on a Russian frame. This boost was generally performed by Progress resupply vessels, although during the Shuttle- Mir programme the task was performed by US Space Shuttles, and, prior to the arrival of Kvant-1 , the engines on the core module could also accomplish the task.

Radio links were also used during rendezvous and docking procedures and for audio and video communication between crew members, flight controllers and family members.

As a result, Mir was equipped with several communication systems used for different purposes. The station communicated directly with the ground via the Lira antenna mounted to the core module.

The Lira antenna also had the capability to use the Luch data relay satellite system which fell into disrepair in the s and the network of Soviet tracking ships deployed in various locations around the world which also became unavailable in the s.

While the constant free fall of the station offered a perceived sensation of weightlessness , the onboard environment was not one of weightlessness or zero gravity.

The environment was often described as microgravity. This state of perceived weightlessness was not perfect, being disturbed by five separate effects: The Elektron system generated oxygen.

Bottled oxygen and solid fuel oxygen generation SFOG canisters, a system known as Vika , provided backup. Carbon dioxide was removed from the air by the Vozdukh system.

Similar systems are presently used on the ISS. Intercosmos "ИнтерКосмос" Interkosmos was a Soviet Union space exploration programme which allowed members from the military forces of allied Warsaw Pact countries to participate in manned and unmanned space exploration missions.

Participation was also made available to governments of countries, such as France and India. Various European astronauts visited Mir as part of several cooperative programmes: In the early s, NASA planned to launch a modular space station called Freedom as a counterpart to Mir , while the Soviets were planning to construct Mir -2 in the s as a replacement for the station.

The post-Soviet economic chaos in Russia also led to the cancellation of Mir -2, though only after its base block, DOS-8 , had been constructed.

Bush and Russian president Boris Yeltsin agreed to cooperate on space exploration. The project prepared the way for further cooperative space ventures, specifically, "Phase Two" of the joint project, the construction of the ISS.

The programme was announced in ; the first mission started in , and the project continued until its scheduled completion in Eleven Space Shuttle missions, a joint Soyuz flight, and almost cumulative days in space for US astronauts occurred over the course of seven long-duration expeditions.

It commonly housed three crew members, but was capable of supporting as many as six for up to a month. The station was designed to remain in orbit for around five years; it remained in orbit for fifteen.

The windows were covered during night hours to give the impression of darkness because the station experienced 16 sunrises and sunsets a day.

A typical day for the crew began with a wake-up at Work was conducted from Three more hours of work and another hour of exercise followed lunch, and the crews began preparing for their evening meal at about The cosmonauts were free to do as they wished in the evening, and largely worked to their own pace during the day.

NASA astronaut Jerry Linenger related how life on board Mir was structured and lived according to the detailed itineraries provided by ground control.

Every second on board was accounted for and all activities were timetabled. After working some time on Mir , Linenger came to feel that the order in which his activities were allocated did not represent the most logical or efficient order possible for these activities.

He decided to perform his tasks in an order that he felt enabled him to work more efficiently, be less fatigued, and suffer less from stress.

Linenger noted that his comrades on Mir did not "improvise" in this way, and as a medical doctor he observed the effects of stress on his comrades that he believed was the outcome of following an itinerary without making modifications to it.

Despite this, he commented that his comrades performed all their tasks in a supremely professional manner.

Astronaut Shannon Lucid , who set the record for longest stay in space by a woman while aboard Mir surpassed by Sunita Williams 11 years later on the ISS , also commented about working aboard Mir saying "I think going to work on a daily basis on Mir is very similar to going to work on a daily basis on an outstation in Antarctica.

The big difference with going to work here is the isolation, because you really are isolated. You really are on your own. The most significant adverse effects of long-term weightlessness are muscle atrophy and deterioration of the skeleton , or spaceflight osteopenia.

Other significant effects include fluid redistribution, a slowing of the cardiovascular system , decreased production of red blood cells , balance disorders, and a weakening of the immune system.

Lesser symptoms include loss of body mass, nasal congestion, sleep disturbance, excess flatulence , and puffiness of the face. These effects begin to reverse quickly upon return to the Earth.

To prevent some of these effects, the station was equipped with two treadmills in the core module and Kvant -2 and a stationary bicycle in the core module ; each cosmonaut was to cycle the equivalent of 10 kilometres 6.

Researchers believe that exercise is a good countermeasure for the bone and muscle density loss that occurs in low-gravity situations.

The user is first fastened to the toilet seat, which was equipped with spring-loaded restraining bars to ensure a good seal.

A lever operated a powerful fan and a suction hole slid open: Solid waste was collected in individual bags which were stored in an aluminium container.

Full containers were transferred to Progress spacecraft for disposal. Liquid waste was evacuated by a hose connected to the front of the toilet, with anatomically appropriate "urine funnel adapters" attached to the tube so both men and women could use the same toilet.

Waste was collected and transferred to the Water Recovery System, where it was recycled back into drinking water, although this was usually used to produce oxygen via the Elektron system.

Mir featured a shower, the Bania , located in Kvant It was an improvement on the units installed in previous Salyut stations, but proved difficult to use due to the time required to set up, use, and stow.

The shower, which featured a plastic curtain and fan to collect water via an airflow, was later converted into a steam room; it eventually had its plumbing removed and the space was reused.

When the shower was unavailable, crew members washed using wet wipes, with soap dispensed from a toothpaste tube-like container, or using a washbasin equipped with a plastic hood, located in the core module.

Crews were also provided with rinse-less shampoo and edible toothpaste to save water. On a visit to Mir , bacteria and larger organisms were found to have proliferated in water globules formed from moisture that had condensed behind service panels.

The station provided two permanent crew quarters, the Kayutkas , phonebox-sized booths set towards the rear of the core module, each featuring a tethered sleeping bag, a fold-out desk, a porthole, and storage for personal effects.

Visiting crews had no allocated sleep module, instead attaching a sleeping bag to an available space on a wall; US astronauts installed themselves within Spektr until a collision with a Progress spacecraft caused the depressurisation of that module.

Most of the food eaten by station crews was frozen, refrigerated or canned. Menus were prepared by the cosmonauts, with the help of a dietitian , before their flight to the station.

Meals were spaced out through the day to aid assimilation. Usually, crews drank tea, coffee and fruit juices, but, unlike the ISS, the station also had a supply of cognac and vodka for special occasions.

In the s samples of extremophile moulds were taken from Mir. By the time of its decommission in , the number of known different micro-organisms had grown to As space stations get older, the problems with contamination get worse.

Some biologists were concerned about the mutant fungi being a major microbiological hazard for humans, and reaching Earth in the splashdown, after having been in an isolated environment for 15 years.

Mir was visited by a total of 28 long-duration or "principal" crews, each of which was given a sequential expedition number formatted as EO-X.

Expeditions varied in length from the day flight of the crew of EO to the day flight of Valeri Polyakov , but generally lasted around six months. Due to the pressure to launch the station on schedule, mission planners were left without Soyuz spacecraft or modules to launch to the station at first.

It was decided to launch Soyuz T on a dual mission to both Mir and Salyut 7. During their nearly day stay on Mir , they brought the station online and checked its systems.

They unloaded two Progress spacecraft launched after their arrival, Progress 25 and Progress On 5 May , they undocked from Mir for a day-long journey to Salyut 7.

Soyuz T redocked with Mir on 26 June and delivered the experiments and 20 instruments, including a multichannel spectrometer.

The EO-1 crew spent their last 20 days on Mir conducting Earth observations before returning to Earth on 16 July , leaving the new station unoccupied.

During their stay, the Kvant -1 module, launched on 30 March , arrived. Kvant -1 was originally planned to dock with Salyut 7 ; due to technical problems during its development, it was reassigned to Mir.

The module carried the first set of six gyroscopes for attitude control. The module also carried instruments for X-ray and ultraviolet astrophysical observations.

The initial rendezvous of the Kvant -1 module with Mir on 5 April was troubled by the failure of the onboard control system.

After the failure of the second attempt to dock, the resident cosmonauts, Yuri Romanenko and Aleksandr Laveykin , conducted an EVA to fix the problem.

They found a trash bag which had been left in orbit after the departure of one of the previous cargo ships and was now located between the module and the station, which prevented the docking.

After removing the bag, docking was completed on 12 April. The Soyuz TM-2 launch was the beginning of a string of 6 Soyuz launches and three long-duration crews between 5 February and 27 April The launch of Soyuz TM-8 on 5 September marked the beginning of the longest human presence in space, until 23 October , when this record was surpassed by the ISS.

The Kvant-2 and Kristall modules were now ready for launch. Alexander Viktorenko and Aleksandr Serebrov docked with Mir and brought the station out of its five-month hibernation.

After a day delay caused by faulty computer chips, Kvant -2 was launched on 26 November Kvant -2 added a second set of gyrodines to Mir , and brought the new life support systems for recycling water and generating oxygen, reducing dependence on ground resupply.

The module featured a large airlock with a one-metre hatch. While docking, the EO-5 crew noted that three thermal blankets on the ferry were loose, potentially creating problems on reentry, but it was decided that they would be manageable.

Their stay on board Mir saw the addition of the Kristall module, launched 31 May The first docking attempt on 6 June was aborted due to an attitude control thruster failure.

Kristall arrived at the front port on 10 June and was relocated to the lateral port opposite Kvant -2 the next day, restoring the equilibrium of the complex.

Kristall contained furnaces for use in producing crystals under microgravity conditions hence the choice of name for the module.

The module was also equipped with biotechnology research equipment, including a small greenhouse for plant cultivation experiments which was equipped with a source of light and a feeding system, in addition to equipment for astronomical observations.

Although they were never used in a Buran docking, they were useful later during the Shuttle- Mir programme, providing a berthing location for US Space Shuttles.

The crew launched as Soviet citizens and returned to earth as Russians. Bush announced what would later become the Shuttle- Mir programme, a cooperative venture which proved useful to the cash-strapped Roskosmos and led to the eventual completion and launch of Spektr and Priroda.

Throughout the period following the collapse of the USSR, crews on Mir experienced occasional reminders of the economic chaos occurring in Russia. The initial cancellation of Spektr and Priroda was the first such sign, followed by the reduction in communications as a result of the fleet of tracking ships being withdrawn from service by Ukraine.

Various Progress spacecraft had parts of their cargoes missing, either because the consumable in question had been unavailable, or because the ground crews at Baikonur had looted them.

The problems became particularly obvious during the launch of the EO crew aboard Soyuz TM in July; shortly before launch there was a black-out at the pad, and the power supply to the nearby city of Leninsk failed an hour after launch.

The EO crew departed on 22 July, and soon after Mir passed through the annual Perseid meteor shower , during which the station was hit by several particles.

The undocking was unusual in that the spacecraft was to pass along Kristall in order to obtain photographs of the APAS to assist in the training of space shuttle pilots.

Due to an error in setting up the control system, the spacecraft struck the station a glancing blow during the manoeuvre, scratching the exterior of Kristall.

The launch of Soyuz TM , carrying the EO crew, was delayed due to the unavailability of a payload fairing for the booster that was to carry it, but the spacecraft eventually left Earth on 1 July and docked two days later.

They stayed only four months to allow the Soyuz schedule to line up with the planned space shuttle manifest, and so Polyakov greeted a second resident crew in October, prior to the undocking of Soyuz TM, when the EO crew arrived in Soyuz TM The EO crew left a few days later, with Polyakov completing his record-breaking day spaceflight.

During EO, the Spektr science module which served as living and working space for American astronauts was launched aboard a Proton rocket and docked to the station, carrying research equipment from America and other nations.

This mission saw the first joint US spacewalk on Mir take place deploying the Mir Environmental Effects Payload package on the docking module. This, the fourth docking, saw John Blaha transferring onto Mir to take his place as resident US astronaut.

The power failure also caused a loss of attitude control , which led to an uncontrolled "tumble" through space. Following the 8 June departure of Discovery , the EO crew of Budarin and Musabayev remained on Mir , completing materials experiments and compiling a station inventory.

On 2 July, Roskosmos director Yuri Koptev announced that, due to a lack of funding to keep Mir active, the station would be deorbited in June Roscosmos confirmed that it would not fund Mir past the set deorbit date.

The crew carried out three EVAs to retrieve experiments and deploy a prototype communications antenna on Sofora. On 1 June it was announced that the deorbit of the station would be delayed by six months to allow time to seek alternative funding to keep the station operating.

The rest of the expedition was spent preparing the station for its deorbit; a special analog computer was installed and each of the modules, starting with the docking module, was mothballed in turn and sealed off.

The crew loaded their results into Soyuz TM and departed Mir on 28 August , ending a run of continuous occupation, which had lasted for eight days short of ten years.

The privately funded Soyuz TM mission by MirCorp , launched on 4 April , carried two crew members, Sergei Zalyotin and Aleksandr Kaleri , to the station for two months to do repair work with the hope of proving that the station could be made safe.

This began with the docking of Progress M , a modified version of the Progress-M carrying 2. Major destruction of the station began around Mir was primarily supported by the Russian Soyuz and Progress spacecraft and had two ports available for docking them.

Soyuz spacecraft provided manned access to and from the station allowing for crew rotations and cargo return, and also functioned as a lifeboat for the station, allowing for a relatively quick return to Earth in the event of an emergency.

A total of 31 30 manned, 1 unmanned Soyuz spacecraft flew to the station over a fourteen-year period. The unmanned Progress cargo vehicles were only used to resupply the station, carrying a variety of cargoes including water, fuel, food and experimental equipment.

The spacecraft were not equipped with reentry shielding and so, unlike their Soyuz counterparts, were incapable of surviving reentry.

In addition to the routine Soyuz and Progress flights, it was anticipated that Mir would also be the destination for flights by the Soviet Buran space shuttle , which was intended to deliver extra modules based on the same "37K" bus as Kvant -1 and provide a much improved cargo return service to the station.

One port was to be used for Buran ; the other for the planned Pulsar X-2 telescope, also to be delivered by Buran.

With a space shuttle docked to Mir , the temporary enlargements of living and working areas amounted to a complex that was the largest spacecraft in history at that time, with a combined mass of tonnes short tons.

An extra A added to the end of mammalian miR , a liver-enriched miRNA important in hepatitis C , stabilizes the molecule and plant miRNAs ending with an adenine residue have slower decay rates.

The function of miRNAs appears to be in gene regulation. Recent work on miR in zebrafish, as well as on bantam-miRNA and miR-9 in Drosophila cultured cells, shows that translational repression is caused by the disruption of translation initiation , independent of mRNA deadenylation.

Nine mechanisms of miRNA action are described and assembled in a unified mathematical model: It is often impossible to discern these mechanisms using experimental data about stationary reaction rates.

Nevertheless, they are differentiated in dynamics and have different kinetic signatures. Interactions between microRNAs and complementary sequences on genes and even pseudogenes that share sequence homology are thought to be a back channel of communication regulating expression levels between paralogous genes.

New microRNAs are created in multiple ways. However, the difference in how these microRNAs function and the way they are processed suggests that microRNAs arose independently in plants and animals.

Focusing on the animals, the genome of Mnemiopsis leidyi [] appears to lack recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha , which are critical to canonical microRNA biogenesis.

It is the only animal thus far reported to be missing Drosha. MicroRNAs play a vital role in the regulation of gene expression in all non-ctenophore animals investigated thus far except for Trichoplax adhaerens , the only known member of the phylum Placozoa.

Across all species, in excess of different miRNAs had been identified by March While researchers focused on miRNA expression in physiological and pathological processes, various technical variables related to microRNA isolation emerged.

The stability of stored miRNA samples has been questioned. This makes it necessary to cool samples on ice and use RNase -free equipment.

Variations of this method achieve absolute or relative quantification. The locked conformation of LNA results in enhanced hybridization properties and increases sensitivity and selectivity, making it ideal for detection of short miRNA.

High-throughput quantification of miRNAs is error prone, for the larger variance compared to mRNAs that comes with methodological problems. Just as miRNA is involved in the normal functioning of eukaryotic cells, so has dysregulation of miRNA been associated with disease.

A manually curated, publicly available database, miR2Disease , documents known relationships between miRNA dysregulation and human disease.

A mutation in the seed region of miR, causes hereditary progressive hearing loss. A mutation in the seed region of miR, causes hereditary keratoconus with anterior polar cataract.

The first human disease known to be associated with miRNA deregulation was chronic lymphocytic leukemia. Many other miRNAs also have links with cancer and accordingly are sometimes referred to as " oncomirs ".

Another role for miRNA in cancers is to use their expression level for prognosis. Furthermore, specific miRNAs may be associated with certain histological subtypes of colorectal cancer.

For instance, expression levels of miR and miR have been shown to be increased in mucinous colorectal cancers and mucin-producing Ulcerative Colitis-associated colon cancers, but not in sporadic colonic adenocarcinoma that lack mucinous components.

Hepatocellular carcinoma cell proliferation may arise from miR interaction with MAP2K3, a tumor repressor gene. Those with a rapid response to initial treatment may benefit from truncated treatment regimens, showing the value of accurate disease response measures.

Cell-free miRNA are highly stable in blood, are overexpressed in cancer and are quantifiable within the diagnostic laboratory.

In classical Hodgkin lymphoma , plasma miR, miR, and miR are promising disease response biomarkers. They can be performed at each consultation to assess disease response and detect relapse.

MicroRNAs have the potential to be used as tools or targets for treatment of different cancers. A significant number of cervical cancer samples were found to have downregulated expression of miR Additionally, miR works to promote apoptosis of cervical cancer cells, through its direct target hedgehog pathway transcription factor, Gli3.

DNA damage is considered to be the primary underlying cause of cancer. Such damage can cause mutational errors during DNA replication due to error-prone translesion synthesis.

Accumulated damage can also cause epigenetic alterations due to errors during DNA repair. HMGA expression is almost undetectable in differentiated adult tissues, but is elevated in many cancers.

Human neoplasias, including thyroid, prostatic, cervical, colorectal, pancreatic and ovarian carcinomas, show a strong increase of HMGA1a and HMGA1b proteins.

The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart.

This revealed that miRNAs play an essential role during its development. Murine microRNA is a potential biomarker i.

These findings were observed in ligated carotid arteries of mice to mimic the effects of d-flow. Within 24 hours, pre-existing immature miR formed mature miR suggesting that miR is flow-sensitive.

Arterial ECM is mainly composed of collagen and elastin fibers, providing the structural support and recoil properties of arteries.

Consistent with these findings, inhibition of pre-miR increases expression of TIMP3 in cells, even when exposed to turbulent flow. When tested, d-flow decreased the expression of XRN1 in humans as it did in mice endothelial cells, indicating a potentially common role of XRN1 in humans.

Targeted deletion of Dicer in the FoxD1 -derived renal progenitor cells in a murine model resulted in a complex renal phenotype including expansion of nephron progenitors, fewer renin cells, smooth muscle arterioles , progressive mesangial loss and glomerular aneurysms.

Using a lineage tracing approach followed by Fluorescent-activated cell sorting , miRNA profiling of the FoxD1-derived cells not only comprehensively defined the transcriptional landscape of miRNAs that are critical for vascular development, but also identified key miRNAs that are likely to modulate the renal phenotype in its absence.

Consistent with the profiling results, ectopic apoptosis was observed in the cellular derivatives of the FoxD1 derived progenitor lineage and reiterates the importance of renal stromal miRNAs in cellular homeostasis.

The vital role of miRNAs in gene expression is significant to addiction , specifically alcoholism. Another class of miRNAs that regulate insulin resistance , obesity , and diabetes , is the let-7 family.

Let-7 accumulates in human tissues during the course of aging. Not only could let-7 inhibition prevent obesity and diabetes, it could also reverse and cure the condition.

When the human genome project mapped its first chromosome in , it was predicted the genome would contain over , protein coding genes. However, only around 20, were eventually identified.

Hence, miRNAs play a key role in host—virus interactions and pathogenesis of viral diseases. It is of key importance to identify the miRNA targets accurately.

From Wikipedia, the free encyclopedia. Annual Review of Biochemistry. Annual Review of Genetics. Annual Review of Plant Biology.

The Journal of Biological Chemistry. The Journal of Endocrinology. Molecular Genetics and Metabolism. Biochimica et Biophysica Acta.

Methods in Molecular Biology. Current Opinion in Cell Biology. Current Topics in Microbiology and Immunology.

Release Mechanisms, Functions and Challenges". Achievements in the Life Sciences. International Journal of Cardiology.

Nucleic Acids Symposium Series. Cellular and Molecular Life Sciences.

Author: Yozshujas

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